Top 7 Anti-Aging & Longevity Peptides

GHK-Cu (copper peptide) is a naturally occurring tripeptide with a strong affinity for copper(II) ions. First identified in human plasma by Dr. Loren Pickart in 1973, GHK-Cu concentration declines with age. It has become one of the most studied peptides in dermatological and aging research, with applications spanning skin biology, wound healing, and gene expression modulation.

Epitalon (also spelled Epithalon) is a synthetic tetrapeptide based on the naturally occurring peptide epithalamin, which is produced by the pineal gland. Developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology, Epitalon has been the subject of extensive research into telomerase activation, telomere biology, and age-related biomarkers in preclinical models.

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a mitochondria-derived peptide discovered by Dr. Changhan Lee at the USC Leonard Davis School of Gerontology in 2015. As one of several recently identified mitochondrial-derived peptides (MDPs), MOTS-c is encoded in the mitochondrial genome rather than the nuclear genome, representing a novel class of signaling molecules.

SS-31 (also known as Elamipretide or Bendavia) is a synthetic tetrapeptide developed by Dr. Hazel Szeto at Weill Cornell Medical College. It is a mitochondria-targeted antioxidant that selectively concentrates in the inner mitochondrial membrane, specifically binding to cardiolipin — a phospholipid critical for mitochondrial electron transport chain function.

BPC-157 (Body Protection Compound-157) is a synthetic peptide consisting of 15 amino acids. It is derived from a partial sequence of a protective protein found in human gastric juice. BPC-157 has become one of the most extensively studied peptides in preclinical research, with over 100 published studies examining its effects in various animal models.

TB-500 is a synthetic analog of Thymosin Beta-4, a naturally occurring 43-amino acid peptide present in virtually all human and animal cells. TB-500 represents the active region of the parent protein and is widely used in research settings to study cell migration, blood vessel formation, and tissue repair mechanisms.

Selank is a synthetic peptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is based on the naturally occurring immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), with an added Pro-Gly-Pro sequence that enhances stability against enzymatic degradation. Selank has been the subject of extensive preclinical research as both a nootropic and immunomodulatory compound.