Top 7 Immune & Inflammation Peptides

Thymosin Alpha-1 (Ta1) is a 28-amino acid peptide originally isolated from thymic tissue by Allan Goldstein at the George Washington University in the 1970s. It is one of the most extensively studied immunomodulatory peptides, with a substantial body of research spanning several decades. A synthetic version (thymalfasin) has been approved as a pharmaceutical product in over 35 countries for various indications.

KPV is a naturally occurring tripeptide derived from the C-terminal end of alpha-melanocyte-stimulating hormone (alpha-MSH). Despite its extremely small size — just three amino acids — KPV retains significant biological activity related to immune modulation and inflammatory pathway regulation. Its simplicity and stability make it an attractive research tool.

Selank is a synthetic peptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. It is based on the naturally occurring immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), with an added Pro-Gly-Pro sequence that enhances stability against enzymatic degradation. Selank has been the subject of extensive preclinical research as both a nootropic and immunomodulatory compound.

BPC-157 (Body Protection Compound-157) is a synthetic peptide consisting of 15 amino acids. It is derived from a partial sequence of a protective protein found in human gastric juice. BPC-157 has become one of the most extensively studied peptides in preclinical research, with over 100 published studies examining its effects in various animal models.

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a mitochondria-derived peptide discovered by Dr. Changhan Lee at the USC Leonard Davis School of Gerontology in 2015. As one of several recently identified mitochondrial-derived peptides (MDPs), MOTS-c is encoded in the mitochondrial genome rather than the nuclear genome, representing a novel class of signaling molecules.

TB-500 is a synthetic analog of Thymosin Beta-4, a naturally occurring 43-amino acid peptide present in virtually all human and animal cells. TB-500 represents the active region of the parent protein and is widely used in research settings to study cell migration, blood vessel formation, and tissue repair mechanisms.

GHK-Cu (copper peptide) is a naturally occurring tripeptide with a strong affinity for copper(II) ions. First identified in human plasma by Dr. Loren Pickart in 1973, GHK-Cu concentration declines with age. It has become one of the most studied peptides in dermatological and aging research, with applications spanning skin biology, wound healing, and gene expression modulation.