Top 7 Growth Hormone Secretagogues Peptides

CJC-1295 is a synthetic analog of growth hormone-releasing hormone (GHRH) consisting of 29 amino acids. It was developed by ConjuChem Biotechnologies and exists in two research forms: with and without Drug Affinity Complex (DAC). The DAC-modified version binds to albumin, dramatically extending its half-life. CJC-1295 is one of the most studied growth hormone secretagogues in preclinical research.

Ipamorelin is a synthetic pentapeptide growth hormone secretagogue that acts as a selective agonist of the ghrelin/GHS receptor (GHS-R1a). Developed by Novo Nordisk, it is considered one of the most selective GH secretagogues studied, producing GH release with minimal effects on other hormones such as cortisol, ACTH, and prolactin in preclinical research models.

GHRP-6 (Growth Hormone Releasing Peptide-6) is a synthetic hexapeptide that acts as a potent growth hormone secretagogue through the ghrelin receptor (GHS-R1a). Developed in the 1980s by Cyril Bowers, GHRP-6 was one of the first synthetic GH-releasing peptides discovered and has served as a foundational research tool for understanding the ghrelin-GH axis.

Semax is a synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10), developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. Like Selank, it incorporates a Pro-Gly-Pro C-terminal modification for enhanced stability. Semax has been extensively studied in Russian preclinical and clinical research as a neuroprotective and nootropic compound.

BPC-157 (Body Protection Compound-157) is a synthetic peptide consisting of 15 amino acids. It is derived from a partial sequence of a protective protein found in human gastric juice. BPC-157 has become one of the most extensively studied peptides in preclinical research, with over 100 published studies examining its effects in various animal models.

TB-500 is a synthetic analog of Thymosin Beta-4, a naturally occurring 43-amino acid peptide present in virtually all human and animal cells. TB-500 represents the active region of the parent protein and is widely used in research settings to study cell migration, blood vessel formation, and tissue repair mechanisms.

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a mitochondria-derived peptide discovered by Dr. Changhan Lee at the USC Leonard Davis School of Gerontology in 2015. As one of several recently identified mitochondrial-derived peptides (MDPs), MOTS-c is encoded in the mitochondrial genome rather than the nuclear genome, representing a novel class of signaling molecules.