PT-141
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH). It was originally developed from the tanning peptide Melanotan II and acts as a melanocortin receptor agonist, primarily targeting MC3R and MC4R receptors in the central nervous system. PT-141 is notable as one of the few peptides that acts through central nervous system pathways rather than peripheral vascular mechanisms.
Research Overview
PT-141 emerged from melanocortin research at the University of Arizona in the 1990s. The compound was identified during studies of Melanotan II when researchers observed unexpected central nervous system effects in animal models. Published research in journals including the Journal of Urology and Pharmacology Biochemistry and Behavior has examined its melanocortin receptor binding profile and downstream signaling in rodent models. The peptide's selectivity for MC3R and MC4R receptors in hypothalamic regions distinguishes it mechanistically from other compounds studied in similar contexts. Research has focused on understanding the melanocortin pathway's role in CNS-mediated physiological responses, making PT-141 an important tool for mapping these receptor systems.
Key Research Findings
- 1
Acts as an agonist at MC3R and MC4R melanocortin receptors in CNS tissue preparations
- 2
Demonstrated central nervous system activity in rodent behavioral models (Hadley & Dorr, 2006)
- 3
Derived from Melanotan II research at the University of Arizona melanocortin program
- 4
Distinguished by mechanism of action through hypothalamic pathways in animal studies
- 5
Used as a research tool to map melanocortin receptor distribution in brain tissue
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Cyclic structure provides improved stability compared to linear melanocortin analogs in vitro
Where to Buy PT-141
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Related Peptides
Molecular Details
- Sequence
- Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
- Molecular Weight
- 1,025.2 g/mol
- Molecular Formula
- C50H68N14O10
Storage & Handling
- Storage
- Store lyophilized at -20C. Reconstituted at 4C, use within 10 days.
- Solubility
- Soluble in sterile water and bacteriostatic water.
Categories
Research Disclaimer: All information on this page is provided for educational and research purposes only. Products discussed are intended for laboratory research use exclusively. They are not intended for human consumption, therapeutic use, or as dietary supplements. Always follow institutional guidelines and consult published peer-reviewed literature for research protocol development. Not for human consumption.